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Results were analyzed using paired t-tests compared to baseline visit, with each individual compared to themselves at baseline. We agree with guidelines recommending that these individuals should be monitored for changes in lipid parameters as estrogen is well known to induce hypertriglyceridemia in some individuals. Patients on testosterone should be monitored every 3 months for one year and then every 6 to 12 months thereafter. Recently, there has been a dramatic increase in public awareness of transgender individuals due to mainstream media exposure of trans celebrities such as athlete Caitlyn Jenner and Orange is the New Black actress Laverne Cox. World Journal of Urology. Estrogens may increase the risk of gallbladder diseaseespecially in older and obese people. The goal of this study was to determine if transgender hormone therapy with estrogen and spironolactone for male-to-female MtF patients or with testosterone for female-to-male FtM patients had adverse anthropomorphic or metabolic effects.

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This is no longer the case, as clinical evidence has showed a strong relationship between ethinyl estradiol and the incidence of deep venous thrombosis

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Metabolic Effects of Hormone Therapy in Transgender Patients

Adult and Pediatric E-Book. The major risks associated with spironolactone include hyperkalemia and blood pressure effects, particularly if subjects have underlying renal or liver disease. Because hormone therapy is usually the first physical step taken to transition, the act of beginning it has a significant psychological effect, which is difficult to distinguish from hormonally induced changes. It cannot undo many of the changes produced by naturally occurring pubertywhich may necessitate surgery and other treatments to reverse see below. Stretch marks striae distensae may appear on the skin in these areas. The therapy used resembles hormone replacement regimens used to treat natal men with hypogonadism and most of the preparations are testosterone esters. We agree with guidelines recommending that these individuals should be monitored for changes in lipid parameters as estrogen is well known to induce hypertriglyceridemia in some individuals.

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Journal of Mammary Gland Biology and Neoplasia. Pathology, Diagnosis and Treatment: Induced Lactation in a Transgender Woman". In clinical trialscisgender women have used stem cells from fat to regrow their breasts after mastectomies. The most significant cardiovascular risk for transgender women is the prothrombotic effect increased blood clotting of estrogens.